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The Application of Charge Density Research to Chemistry and Drug Design 53 Andererseits drücken sie auch dieIn the past twenty years, the X ray crystallography of organic molecules has expanded rapidly in two opposite directions. One is towards larger and larger biological macromolecules and the other is towards the fine details of the electronic structure of small molecules. Both advances required the development of more sophisticated methodologies. Both were made possible by the rapid development of computer technology. X ray diffraction equipment has